Maelys

Auffret

Research Topic

My research focuses on systemic and muscular iron metabolism regulation in physiopathological conditions. 

Iron is essential for numerous physiological processes and is particularly abundant in red blood cells in hemoglobin, and skeletal muscle in myoglobin. Previous studies have reported relationships between muscle wasting and iron overload, but the underlying mechanisms in these conditions are incompletely characterised. The aim of my work is to characterize in vivo the regulatory mechanisms of iron metabolism under pathophysiological conditions, using models of iron supplementation and muscle atrophy (extreme physical inactivity, cancer cachexia).